Figure 4 of Fang, Mol Vis 2020; 27:354-364.


Figure 4. Downregulation of Piezo2 in the TM through the Cre-lox system. A: Piezo2 expression in iridocorneal angle tissues of Piezo2fl/fl mice (n = 4) receiving adenovirus 5 (Ad5)-Cre decreased by 21.4% and 35.1% in the first and second weeks relative to the Ad5-Con injected mice (p = 0.04). P values were obtained from one-way analysis of variance (ANOVA). B: Through the Cre-lox system, a statistically significant decrease in Piezo2 expression (red) was observed in the trabecular meshwork (TM), ciliary body, and ciliary muscle with immunohistochemical analysis (n = 6). The nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI) in blue. Scale bar: 100 µm.