Figure 5. Comparison of the mean concentrations of biomarkers CST4 (A), S100A6 (B), and MMP9 (C) in control (CT; n = 14) and dry eye (DE) groups according to the severity (mild, n = 11; moderate, n = 14; and severe, n = 7), measured using standard individual ELISA assays and customized multiplexed antibody microarrays. The concentration is expressed in ng/ml. The insert in the S100A6 plot shows the details of the results obtained using ELISA assays. Error bars show standard deviation, and * indicates statistical significance relative to the corresponding control group (p value <0.05).