Table 1 of McClements, Mol Vis 2021; 27:233-242.

Table 1. Nucleotide frequencies at positions −9 to −1 relative to the start codon for 135 genes that cause inherited retinal disease.

Nucleotide frequencies for 135 genes causing non-syndromic inherited retinal disease
  -9 -8 -7 -6 -5 -4 -3 -2 -1
A 25 16 20 16 16 24 50 29 18
G 32 26 26 42 30 30 40 19 27
C 21 38 36 27 37 35 8 45 49
T 22 21 18 14 18 10 2 7 6
Preference: G C C G C C A C C
Nucleotide frequencies previously identified for 32,526 human genes
A 20 20 21 21 19 24 46 29 19
G 35 29 28 39 30 26 37 20 28
C 27 33 32 23 32 38 10 38 45
T 18 18 19 17 19 12 7 13 8
Preference: G C C G C C A C C
                   
Chi-square: 0.254 0.457 0.847 0.404 0.674 0.757 0.011 0.066 0.769

The nucleotide frequencies for 135 genes listed in Appendix 1 that cause inherited retinal disease are compared to the nucleotide frequencies of 32,526 human genes previously published [6].

McClements, Mol Vis 2021; 27:233-242. http://www.molvis.org/molvis/v27/233

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