Figure 2. Neuroprotective effects of SAHA in rd1 organ cultures. Rd1 retina-RPE sandwich organ cultures were grown for 10 days from postnatal day 10 to 20, during which the majority of photoreceptors degenerate in vehicle-treated samples. Vorinostat (suberoylanilide hydroxamic acid, SAHA) was found to reduce the amount of cell loss in a dose-dependent manner. A: Representative samples of retina sections are shown. B: Cell counts over ten locations across the explant culture document a twofold increase in average cell numbers with 1 μM SAHA. Data are shown as mean ± standard error of the mean (SEM; n = 3–4), or representative images are shown.