Figure 3. Pedigrees of three retinoblastoma familial cases. A: The mother's left eye and both eyes of the sister and the proband were affected by a splicing variant (c.1332+3A>C). B: Both eyes of the father and the proband were affected by a splicing variant (c.265-2A>G). C: The father's left eye and both eyes of the proband were affected by a splicing variant (c.1421+1G>A). Blackened symbols: bilateral RB; half-blackened symbols: unilateral RB.