Human mitochondrial genome and detection of primary mutations in LHON samples. A
: Schematic representation of the human mtDNA map indicating 37 genes including MT-ND1, MT-ND4 and MT-ND6 as well as the positions
of primary mutations. Figure adapted from chimerasthebooks
: The red arrow demonstrates the internal control of digestion in the MT-ND1 gene
product. The yellow arrows indicate the Mae
III restriction, detecting the corresponding mutations marked in blue arrows.