Figure 1. Peters anomaly pedigree PA-101. A: Pedigree PA-101. Filled square and circles: PA-affected. Unfilled shapes: not affected with PA. B: Chromatograms showing homozygous and heterozygous mutation c.4978G>A (p.Val1660Ile) in DOP1B, and the wild-type genotype. C: Amino acid sequence alignments showing conservation of Val at positions corresponding to p.1660 in the human DOP1B-encoded protein in orthologous proteins of other organisms.