Figure 4. Treatment with tofacitinib suppresses the proportions of proliferating (Ki67+) cells in the affected eyes. Cell preparations of eye-infiltrating cells were prepared as detailed in the Materials and Methods
section. The percentage of Ki67+ cells among the CD4 and CD8 cells was determined with flow cytometry. On the left, actual data of a representative experiment
and on the right, summary of data from three independent experiments, with each group consisting of five mice. Data shown
as mean ± standard error of the mean (SEM). Statistical significance was determined using an unpaired t test. *p<0.05.