Figure 4. Functional bioinformatics analysis of POAG-associated proteins of the human sclera. A–C: Visualization of Gene Ontology (GO) enrichment analysis performed using the Protein ANalysis THrough Evolutionary Relationships (PANTHER) categories cellular component (A), biologic process (B), and molecular function (C). D: Protein–protein interactions (PPI) network built using STRING. All nodes are characterized by a combined interaction score of >0.4. In addition to the analyzed proteins, the network includes the following potential contributors: alpha-2-HS-glycoprotein (AHSG), S100-A10 protein, collagen alpha-1(I) chain (COL1A1), collagen alpha-1(III) chain (COL3A1), and collagen alpha-2(VI) chain (COL6A2).