Figure 4. Proliferation of RPE cells is inhibited by blocking IL-6/JAK1/STAT3 signaling. A: EdU staining analysis of proliferation of RPE cells after interleukin-6 (IL-6) stimulation with or without S3I-201 (5.0
μM) for 48 h. Scale bars: 40 μm. B: Quantification of EdU-positive cells (n = 24 randomized fields per group). P value versus the IL-6 treated group is shown
(one-way analysis of variance [ANOVA] with the Tukey-Kramer multiple comparison test).