Figure 2. Locations of PDVs and domains in proteins of nine genes are shown by lollipop structures. Sites F114, Y115, N124, R127, H128, and K148 as DNA binding sites are shown with a red line in the forkhead domain of FOXC1 (UniProt/Q12948). Copper ion binding sites (His449, His451, and H453) located in the lysyl oxidase domain of LOXL1 are shown with a green line (Uniprot/Q08397). Sites D380, N428, A429, I477, and D478 as calcium ion binding sites are shown with a blue line in the olfactomedin (OLF) domain of MYOC (Uniprot/Q99972).