Figure 1. Genetic analysis of chromosome 3p21-linked pedigrees harboring mutations in FYCO1. A: Pedigree illustrating the segregation of a single base substitution (c.4270C>T; p.Arg1424Ter) in all available affected and unaffected members of PKCC193. B: Pedigree illustrating the segregation of a single base deletion (c.3196delC; p.His1066IlefsTer10) in all available affected and unaffected members of PKCC202. C: Illustration of a pedigree showing the segregation of a single base change (c.4127T>C; p.Leu1376Pro) in all available affected and unaffected members of PKCC220. The haplotypes of six 3p21 microsatellite markers are shown. The alleles forming the risk haplotype are in black, and the alleles not cosegregating with cataract are shown in white. Note: Squares: males; circles: females; filled symbols: affected individuals; double line between individuals: consanguinity; diagonal line through a symbol: deceased family member.