Figure 2 of Tanaka, Mol Vis 2019; 25:902-911.


Figure 2. Purified intermediate poly-granulins and granulins still have a protective effect on photoreceptor cells. A: Recombinant progranulin (PGRN) was incubated for 1 h, and then cleaved PGRN was fractionated with the centrifugal filter (lane 1 recombinant PGRN, lane 2 cleaved PGRN, lane 3 intermediate poly-granulins and granulins). An arrowhead marks the full-length PGRN. B: Full-length PGRN and granulins with intermediate poly-granulins rescued the cell death induced by light exposure. Data are shown as mean ± standard error of the mean (SEM; n = 6 or 9). ##, p<0.01 versus control; **, p<0.01 versus vehicle (Tukey’s test).