Figure 3. Clinical imagining of patient 3 with a novel c.677T>C mutation in RHO (p.Leu226Pro). A, E: Oculus dexter (OD) color photos showing RPE hypopigmentation and atrophic changes with bone spicules most prominent along the inferior arcades. B, F: Oculus sinister (OS) color photos showing RPE hypopigmentation and atrophic changes with bone spicules most prominent along the inferior arcades. C, G: OD fundus autofluorescence (FAF) photos showing crescent-shaped hyper-autofluorescence (hyperAF) contouring the fovea inferiorly and temporally as well as the optic nerve nasally. There is also a patchy pattern of hypoautofluorescence (hypoAF) along the inferior arcades just adjacent to the previously mentioned crescent-shaped hyperAF. F, H: OS FAF photos showing crescent-shaped hyperAF contouring the fovea inferiorly and temporally as well as the optic nerve nasally. There is also a patchy pattern of hypoAF along the inferior arcades just adjacent to the previously mentioned crescent-shaped hyperAF. I: OD foveal spectral-domain optical coherence tomography (SD-OCT) showing parafoveal retinal thinning and loss of the ellipsoid zone. J: OS foveal SD-OCT showing parafoveal retinal thinning and loss of the ellipsoid zone. K: OS Goldman visual field showing superior hemifield defects between the 10^th and 30^th degrees. L: OD Goldman visual field showing superior hemifield defects between the 10^th and 30^th degrees.