Table 3 of
Xu, Mol Vis 2019; 25:834-842. Table 3 of
Xu, Mol Vis 2019; 25:834-842.
Table 3. Frequencies of alleles and genotypes of PRKCQ and REL polymorphisms in VKH patients and controls in the first-stage study.
| SNP | Genotype allele | Cases (n=600) | Controls (n=1000) | P value | Pc | OR (95% CI) |
|---|---|---|---|---|---|---|
| rs4750316 | GG | 554 (92.33) | 842 (84.2) | Reference | ||
| GC | 44 (7.33) | 153 (15.3) | 2.50e-6 | 6.00e-5 | 0.44 (0.31–0.62) | |
| CC | 2 (0.34) | 5 (0.5) | 0.55 | NS | 0.61 (0.12–3.14) | |
| G | 1152 (96.00) | 1837(91.85) | Reference | |||
| C | 48 (4.00) | 163 (8.15) | 4.66e-6 | 1.12e-4 | 0.47 (0.34–0.65) | |
| rs11258747 | GG | 549 (91.50) | 867 (86.7) | Reference | ||
| GT | 49 (8.20) | 131 (13.1) | 0.0026 | NS | 0.59 (0.42–0.83) | |
| TT | 2 (0.30) | 2 (0.2) | 0.65 | NS | 1.58 (0.22–11.24) | |
| G | 1147 (95.60) | 1865 (93.30) | Reference | |||
| T | 53 (4.40) | 135 (6.8) | 0.0066 | NS | 0.64 (0.46–0.88) | |
| rs947474 | AA | 379(63.17) | 686 (68.60) | Reference | ||
| AG | 204 (34.00) | 287 (28.70) | 0.024 | NS | 1.29 (1.03–1.60) | |
| GG | 17 (2.83) | 27 (2.70) | 0.68 | NS | 1.14 (0.61–2.12) | |
| A | 962 (80.17) | 1659 (82.95) | Reference | |||
| G | 238 (19.83) | 341 (17.05) | 0.048 | NS | 1.20 (1.00–1.45) | |
| rs842647 | GG | 456 (76.00) | 759 (75.90) | Reference | ||
| GA | 135 (22.50) | 222 (22.20) | 0.92 | NS | 1.01 (0.79–1.29) | |
| AA | 9 (1.50) | 19 (1.90) | 0.56 | NS | 0.79 (0.35–1.76) | |
| G | 1047 (87.25) | 1740 (87.00) | Reference | |||
| A | 153 (12.75) | 260 (13.00) | 0.84 | NS | 0.98 (0.79–1.21) | |
| rs702873 | GG | 418 (69.67) | 732 (73.20) | Reference | ||
| AG | 165 (27.50) | 241 (24.10) | 0.12 | NS | 1.20 (0.95–1.51) | |
| AA | 17 (2.83) | 27 (2.70) | 0.76 | NS | 1.10 (0.59–2.05) | |
| G | 1001 (83.42) | 1705 (85.25) | Reference | |||
| A | 199 (16.58) | 295 (14.75) | 0.17 | NS | 1.15 (0.94–1.40) | |
| rs13031237 | GG | 570 (95.00) | 962 (96.20) | Reference | ||
| GT | 27 (4.50) | 38 (3.80) | 0.48 | NS | 1.20 (0.72–1.99) | |
| TT | 3 (0.50) | 0 (0) | 0.025 | NS | 2.69 (2.52–2.87) | |
| G | 1167 (97.25) | 1962 (98.10) | Reference | |||
| T | 33 (2.75) | 38 (1.90) | 0.11 | NS | 1.46 (0.91–2.34) |