Table 2 of Esquerdo-Barragán, Mol Vis 2019; 25:800-813.
DUB | RNA-seq on total RETINA a | ChIP-seqb | RNA-seq on TISSUES c | PHENOTYPEd | BIOLOGIC PROCESS |
---|---|---|---|---|---|
JOSD1 | Decrease during development in whole retina and in rods, but not in cones. | CRX | Adrenal Gland, Cerebellum, Spleen, Thymus | 3 dpf: eyes shape, abnormal retinotectal projection (ZF) | Involved in endocytosis. Almost no bibliography |
OTUD7B | Low expression throughout development, small increase from P10. Continuous expression in rods. | — | Testis | — | Involved in NFκB signaling. Role as oncogene: via deubiquitination of EGFR |
PAN2 (USP52) | Highly expressed in the retina. Shut down in rods at P21, but maintenance in cones. | CRX | Cerebellum, CNS, Testis, Cortical Plate, Frontal Cortex, Limb, Liver, Placenta, Testis, Urinary Bladder | — | mRNA Deadenylation. |
USP10 | Decrease in rods from P10, but not in cones. | CRX, NRL | Cerebellum, CNS, Cortical Plate, Female Gonad, Frontal Cortex, Limb | CNS necrosis (ZF) | DNA damage. Tumour-associated marker in grastrocarcinoma, and Adrenal tumors, Regulation of NFκB signaling via p53. |
USP11 | Strong shut down in rods and not in cones | — | Cerebellum, CNS, Cortical Plate, Frontal Cortex, Gonadal Fat Pad, Kidney, Large Intestine, Placenta, Testis | — | Transport to the Golgi, Protein folding; NFκB signaling; DNA repair after double-strand DNA breaks. Possibly related to X-linked retinal disorders. |
USP14 | Stable expression in retina, with a slight shut down only in rods. | — | Cerebellum, CNS, Cortical Plate, Frontal Cortex, Liver, Placenta, Testis, | Neuronal phenotype slower adults, early death (D). Reduced USP14 levels cause tremors, abnormal brain morphology, altered synaptic transmission and increased apoptosis (H) | Involved in Parkinson. Role as oncogene in breast, hepatolcellular carcinoma, lung adenocarcinoma. Decreases apoptosis. |
USP15 | Stable expression in retina, with a slight shut down only in rods | NRL | Adrenal Gland, Cerebellum, CNS, Colon, Cortical Plate, Heart, Kidney, Large Intestine, Limb, Testis | 2dpf: small eyes, and at 4dpf: deformed eyes (ZF). | Interferon signaling. Involved in mitophagy. Role as oncogene via TGFβ. |
USP20 | Very low levels of expression in retina, with a slight shut down in rods from P10. | — | Kidney, Thymus | Earlier adult death (D). 3dpf: small eyes (ZF). | NFκB signaling. β2 adrenergic receptor recycling. Tyroid hormone activation. |
USP22 | Highly expressed throughout development with a shut down in rods from P10. | CRX | Testis | (Neuronal) slower adults, early death (D). −/− Homozygotes are embryonic lethal (M) | Role as oncogene in liver, colon, lung, gastric, nasopharyngeal, pancreas (via histone and p53 regulation). |
USP39 | Slight shut down both in retina and rods from P10, but not in cones. | CRX | CNS, Limb, Testis | Larval death (D). 2dpf: small eyes (ZF) | Role in cancer, promotes cell proliferation. |
USP46 | Low expression in rods with a final strong shut down. Moderate-high expression in postnatal cones. | — | Adrenal Gland, Duodenum, Adipocytes, Thymus, Kidney, Spleen, Female Gonad, Mammal Gland, Colon | — | Role in neurotransmission circuitry, involved in behavior. |
USP48 | Strong difference between rods (low) and cones (high) expression. | CRX | Cerebellum, CNS; Placenta | 3dpf: small eyes (ZF) | DNA repair in Fanconi Anemiae. Corticoph adenomesf |