Figure 6 of Minogue, Mol Vis 2019; 25:535-545.


Figure 6. Deletion of Chop in Cx50D47A/D47A mice does not alter Irs2 or Trib3 expression. A, B: Graphs show the fold change of Irs2 (A) and Trib3 (B) mRNAs in 1-month-old homozygous Cx50D47A lenses that were heterozygous (Chop+/−-Cx50D47A/D47A) and homozygous (Chop−/−-Cx50D47A/D47A) for the Chop deletion relative to the levels in wild-type (Chop+/+-Cx50D47A/D47A) littermates as determined by real-time quantitative PCR. The bars represent the geometric mean of the fold change obtained in three independent experiments (black circles) using the value obtained in Chop+/+-Cx50D47A/D47A littermates as the reference (short dashed lines at fold change = +1 and −1).