Figure 3. Deletion of Chop does not affect the extent of opacity or size of Cx50^D47A/D47A lenses. A: Dark-field photomicrographs of lenses from 1-month-old homozygous Cx50D47A mice that were wild type for Chop (Chop^+/+) or heterozygous (Chop^+/−) or homozygous (Chop^−/−) Chop-null. Scale bar: 489 µm. B: Graph showing the quantification of the cataract (opacity) in arbitrary units (a.u.). Data are presented as the mean (bar) + standard error of the mean (SEM). C: Graph showing the equatorial diameters determined from dark-field photomicrographs of lenses from homozygous Cx50D47A mice that were wild type for Chop (Chop^+/+) or heterozygous (Chop^+/−) or homozygous (Chop^−/−) knockout for Chop. Data are presented as the mean (bar) + SEM. For the calculations in B and C, n = 4 sets of littermates containing all three genotypes.