Figure 5 of Zyla, Mol Vis 2019; 25:446-461.

Figure 5. DMF does not induce the Nrf2 target genes HO-1 and NQO1 in the optic nerves or spinal cords of mice experiencing acute EAE. Quantitative real-time PCR (qPCR) data measuring the mRNA expression of the Nrf2 target genes HO-1 and NQO1 from either the optic nerves of the more affected (MA) eyes (A and B) or the spinal cords (C and D) of mice subjected to the indicated treatment regimens. Data graphed as the fold change in the expression of the dimethyl fumarate (DMF)-derived samples compared to that of the vehicle-derived samples. Each qPCR reaction was performed in triplicate (three technical replicates) on the indicated number of mice. Error bars represent ± standard deviation (SD). Data were analyzed with the Student t test, with p<0.05 indicating statistical significance; no values reached statistical significance. ON = optic nerve; SC = spinal cord.