Table 1 of
Nikolaeva, Mol Vis 2019; 25:400-414. Table 1 of
Nikolaeva, Mol Vis 2019; 25:400-414.
Table 1. The basic parameters of photoresponses presented as ratios of post- and pretreated values, obtained in “outer segment out” configuration in Ringer’s solution and after 20 min incubation in drug-containing solution (mean ± SEM); * denotes p < 0.05 versus control, & denotes p < 0.05 versus 0.1% DMSO control.
| Light sensitivity | Aсtivation rate (A) | Turn-off time constant (τoff) | Dark current | Dominant recovery time constant (τD) | |
|---|---|---|---|---|---|
| Control | 0.99±0.04 | 0.75±0.06 | 1.01±0.05 | 1.06±0.04 | 1.01±0.05 |
| (n=10) | (n=10) | (n=10) | (n=10) | (n=10) | |
| Dopamine (0.1 µM) | 0.9±0.06 | 0.89±0.12 | 0.83±0.07 | 0.95±0.04 | 1.11±0.07 |
| (n=12) | (n=12) | (n=12) | (n=12) | (n=11) | |
| Dopamine | 0.74±0.07 | 0.72±0.07 | 0.97±0.14 | 1.02±0.07 | 1.04±0.04 |
| (2.5 µM) | (n=10) * | (n=10) | (n=10) | (n=10) | (n=9) |
| Dopamine (20 µM) | 0.66±0.06 | 0.57±0.10 | 0.8±0.11 | 0.99±0.04 | 0.92±0.08 |
| (n=9) * | (n=9) | (n=9) | (n=9) | (n=8) | |
| Dopamine (50 µM) | 0.71±0.04 | 0.56±0.10 | 0.66±0.05 | 1.05±0.02 | 0.89±0.06 |
| (n=7) * | (n=7) | (n=7) | (n=7) | (n=7) | |
| SKF-38,393 | 0.74±0.04 | 0.83±0.05 | 0.90±0.06 | 1.03±0.02 | 0.87±0.06 |
| (0.1 µM) | (n=10) * | (n=10) | (n=10) | (n=10) | (n=10) |
| SKF-38393 | 0.77±0.04 | 0.76±0.07 | 0.93±0.05 | 1.07±0.03 | 0.83±0.05 |
| (2.5 µM) | (n=9) * | (n=9) | (n=9) | (n=9) | (n=9) |
| SKF-38393 | 0.62±0.05 | 0.60±0.05 | 0.72±0.06 | 1.00±0.02 | 0.75±0.04 |
| (20 µM) | (n=10) * | (n=10) | (n=10) * | (n=10) | (n=10) * |
| SKF-38393 | 0.58±0.08 | 0.47±0.11 | 0.64±0.07 | 1.07±0.04 | 0.62±0.03 |
| (50 µM) | (n=9) * | (n=9) | (n=9) * | (n=9) | (n=8) * |
| Quinpirole (2.5 µM) | 0.86±0.09 | 0.85±0.07 | 1.05±0.11 | 1.05±0.03 | 0.98±0.08 |
| (n=9) | (n=9) | (n=9) | (n=9) | (n=8) | |
| Quinpirole (20 µM) | 0.85±0.08 | 0.71±0.05 | 0.96±0.06 | 1.05±0.03 | 0.94±0.04 |
| (n=10) | (n=10) | (n=10) | (n=10) | (n=9) | |
| Quinpirole (50 µM) | 0.74±0.02 | 0.68±0.05 | 0.82±0.05 | 1.11±0.06 | 0.95±0.03 |
| (n=11) * | (n=11) | (n=11) | (n=11) | (n=11) | |
| Control | 1.00±0.03 | 1.11±0.08 | 1.08±0.10 | 1.03±0.02 | 1.11±0.04 |
| (0.1% DMSO) | (n=5) | (n=5) | (n=5) | (n=5) | (n=5) |
| SKF-83959 | 0.73±0.02 | 0.97±0.07 | 0.78±0.03 | 1.05±0.03 | 1.01±0.07 |
| (50 µM) | (n=10) & | (n=10) | (n=10) & | (n=10) | (n=5) |