Figure 5. Effects of the D₁R agonist SKF-38393 on the basic parameters of rod photoresponses in “outer segment out” configuration. Changes of the parameters presented as a ratio of responses after 20 min of exposure to SKF-38393 to photoresponses in Ringer’s solution. Control (0 µM) data are depicted as a ratio of photoresponses after turning on a jet of drug-free Ringer’s solution to photoresponses before introducing rods into the jet. Effects of SKF-38393 on the light sensitivity (A), activation rate (B), turn-off time constant (C), dark current (D), and dominant recovery time constant (E). Average of 8–10 cells in each group. Error bars represent the standard error of the mean (SEM); * denotes p<0.05 versus control. The significance of differences between different concentrations of the D₁R agonist is indicated by connecting lines between bars; # denotes p<0.05 between concentrations of the D₁R agonist.