Table 2 of Faralli, Mol Vis 2019; 25:237-254.

Table 2. DEX-induced changes in genes involved in phagocytosis.

Gene Name Protein Name Function in Phagocytosis FCHTM1 FCHTM2 FC inRozsa et al # (21)
CD36 CD36 or Thrombospondin receptor class B scavenger receptor of pathogens, thrombospondin, collagen, lipoproteins, etc -10.2‡ -5.3† NR
SIRPA(SHPS1) Signal regulatory protein alpha or Tyrosine-protein phosphatase non-receptor type substrate 1 Don’t eat me signal; binds CD47 -1.6* NC NR
ITGB3 β3 integrin subunit Binds ECM proteins; signals to regulate cytoskeleton 4.8‡ 6.7‡ 3.9
    GTPases, GEFs, GAPs      
ABR Active breakpoint cluster region-related protein Dual GEF/GAP
Negative regulator of phagocytosis -2.3 -1.6 -1.4
CHN 1 (ARHGAP2) N-Chimaerin or α-chimaerin GTPase activating protein (GAP) for Rac1 +3.0 +3.0 1.5
GULP1 PTB domain-containing engulfment adapter protein 1 Regulates engulfment, coordinates Rac1 activity -2.9 -3.6 -2.5
PIK3R1 Phosphoinositide-3-kinase regulatory subunit 1 Phosphorylates phosphatidylinositol; involved in integrin, GPCR, RTK and MAPK signaling 4.1‡ 4.3‡ 2.8
MFGE8 Lactadherin or Milk fat globule-EGF factor 8 protein Eat-me signal; binds β3 and β5 integrin 2.0* 2.0‡ 3.3