Molecular Vision: Tatour, Mol Vis 2019; 25:155-164. Table 1

Table 1. Estimation by moment methods of the age of the c.1921‒9C>G mutation in the PDE6B gene causing autosomal recessive retinitis pigmentosa among Jews from the Caucasus.

Marker	Distance from PDE6B			Allele	LD ^b	Population  growth  rate	Estimated age ^a
	Distance from PDE6B			Allele	LD ^b			Method 1		Method 2
								Method 1		Method 2
	Mb	cM	θ ^δ		δ	d	g₀	g₁	g_1c	g₂	g_2c
D4S3360	0.547	1.69	0.017	5	0.325	0.2	12.3	65.9	78.2	58	70.3
						0.4	7.91	65.9	73.8	58	65.9

D4S3038	0.443	1.37	0.014	8	0.284	0.2	13.4	91.2	104.6	84	97.4
						0.4	8.43	91.2	99.6	84	92.4
D4S43	1.578	4.89	0.049	4	0.188	0.2	7.04	33.3	40.3	31	38
						0.4	5.25	33.3	38.5	31	36
D4S1614	1.982	6.14	0.061	3	0.118	0.2	5.9	33.8	39.7	32	37.9
						0.4	4.68	33.8	38.5	32	36.7
D4S127	2.352	7.29	0.073	5	0.115	0.2	5.05	28.6	33.6	28	33
						0.4	4.26	28.6	32.9	28	32

^ag₁ is the age (number of generations) calculated by use of the method of Risch et al. [19]; g₂ is the age obtained according to the iterative procedure of Reich and Goldstein [18]. The ages adjusted for population growth rate (g_1c and g_2c) were obtained by adding the Luria‒Delbrück correction factor (g₀) to g₁ and g_2c, respectively; g₀ was calculated under the assumptions d=0.2 or=0.4. ^b Linkage disequilibrium, calculated according to Bengtsson and Thomson [16]: δ=(p_d ‒ p_n)/(1 ‒ p_n). ^d Estimated on the basis of physical distance (Mb) by use of the conversion factor 3.1 cM/Mb (derived from the Marshfield genetic map of human chromosome 4) and Kosambi’s map function.