Molecular Vision: Kim, Mol Vis 2019; 25:129-142. Table 2

Table 2. Ocular findings for Yap1^+/− mice by slit-lamp examination and histology.

		2-weeks		2 months		1-year
		Slit-lamp	Histology	Slit-lamp	Histology	Slit-lamp	Histology
Microphthalmia*		2/6 (33%)	4/4 (100%)	3/16 (19%)	7/10 (70%)	7/30 (23%)	20/24 (83%)
Cornea	Thin epithelial layers	-	4/4 (100%)	-	7/10 (70%)	-	20/24 (83%)
	Stromal fibrosis with neovascularization and pigmentation	4/6 (60%)	4/4 (100%)	11/16 (69%)	8/10 (80%)	19/30 (63%)	21/24 (88%)
	Absence of Descemet’s membrane and endothelium	-	4/4 (100%)	-	7/10 (70%)	-	20/24 (83%)
Anterior structure	Collapsed/shallow anterior chamber	4/6 (60%)	4/4 (100%)	11/16 (69%)	8/10 (80%)	19/30 (63%)	21/22^§ (96%)
	Adherence of iris cells inner aspect of the cornea	-	4/4 (100%)	-	8/10 (80%)	-	21/24 (88%)
	Loss of some iris substances with abnormal ICA structures	-	4/4 (100%)	-	7/10 (70%)	-	21/24 (88%)
Lens	No lens finding	-	0/4 (0%)	-	3/10 (30%)	-	12/24 (50%)
	Cataract (degenerated lens fibers, bladder cells, etc.)	-	4/4 (100%)	2/2 (100%)^#	6/7^§ (86%)	4/4 (100%)^#	12/12⁺ (100%)
	Abnormal lens capsules (thin, ruptured, etc.)	-	4/4 (100%)	-	5/7^§ (71%)	-	12/12⁺ (100%)
Retina	Retinoschisis	-	0/4 (0%)	-	2/10 (20%)	-	8/22^§ (36%)
	Retinal detachment	-	0/4 (0%)	-	1/10 (10%)	-	12/22^§ (55%)
	Inflammatory giant cells	-	0/4 (0%)	-	1/10 (10%)	-	15/24 (63%)
	Outer nuclear layer thinning	-	0/4 (0%)	-	2/10 (20%)	-	18/22^§ (82%)
	Disorganized retinal layer (including retinal laminal structure loss)	-	0/4 (0%)	-	1/10 (10%)	-	8/24 (33%)
	Rosette formation (in photoreceptor layer)	-	0/4 (0%)	-	1/10 (10%)	-	2/22^§ (9%)
	Separation of internal limiting membrane	-	0/4 (0%)	-	1/10 (10%)	-	2/22^§ (9%)

The results are presented with “the number of affected eyes/total examined eyes (percentages).” ICA=iridocorneal angle; *microphthalmia was evaluated clinically un-defined eyeball with closed or partial opened eyelid and was histologically measured the axial globe length comparing with age-matched WT, ^#cataract was diagnosed by slit lamp examination only in mice with adequate corneal transparency to enable visualization of the lens, ⁺total number of eyes in which the lens was observed histologically, ^§excluded two eyes with completely disorganized and undeveloped retinas.