Figure 5. Ingenuity pathway analysis (IPA) core analysis of the top 22 canonical pathways, most enriched, in our mouse retinal total phosphoproteome data set, reflecting the diverse functional classifications of identified retinal proteins. Each canonical listed has a minimum of 50 interacting proteins. The actual number or interacting proteins is indicated by the number above the lines connecting the different pathways. “Top” canonicals are determined based on the number of molecules identified in a dataset that are also found in IPA’s predefined canonicals. P values listed adjacent to each canonical describe the “p-value of overlap” of the proteins in our dataset that are contained in that canonical relative to the proteins that define the entire canonical.