Molecular Vision: Geerlings, Mol Vis 2018; 24:75-82. Table 2

Table 2. Distribution and interaction analysis of seven rare AMD-associated genetic variants across five geographical regions.

Gene	Difference in distribution between geographical regions^#	Interaction Analysis*	Overall effect size‡
Gene	p-value	p-value	OR (95%CI)
CFH rs121913059 (p.Arg1210Cys)	0.004	0.665	24.2 (8.9–65.6)
CFI rs141853578 (p.Gly119Arg)	0.707	0.563	3.7 (2.5–5.7)
C3 rs147859257 (p.Lys155Gln)	0.665	0.680	2.8 (2.3–3.4)
C9 rs34882957 (p.Pro167Ser)	0.315	0.572	1.7 (1.5–2.0)
CFH rs148553336	0.053	0.015	0.5 (0.4–0.6)
CFH rs35292876	0.001	0.709	2.3 (2.0–2.6)
CFH rs191281603	0.735	0.980	0.9 (0.7–1.1)

^#Logistic Regression with Firth correction. Individual Wald Chi-Square from likelihood ratio test for each of the variants across the geographical regions. *Interaction Analysis: Effect sizes in entire study and interaction analysis to study potential differences in effect size between cohorts. ‡Overall effect size adjusted for geographical region. Bold values: p value considered significant after Bonferroni correction (p<0.007).