Figure 5 of Smit-McBride, Mol Vis 2018; 24:633-646.


Figure 5. Pathway Analysis of the smoke-induced microRNAs and their target genes. A: MicroRNAs and gene network targeting IL-17A: AGO2 (argonaute 2, RISC catalytic component); BCL6 (B-cell CLL/lymphoma 6); BRAF (B-Raf proto-oncogene, serine/threonine kinase); DICER1 (dicer 1, RNase III); IL-17A (interleukin-17A); LMNA (lamin A/C); miR-106b-3p (miRNAs w/seed CGCACUG); miR-1180-3p (miRNAs w/seed UUCCGGC); mir-126; miR-127-3p (miRNAs w/seed CGGAUCC); mir-130; miR-151-3p (and other miRNAs w/seed UAGACUG); miR-151-5p (and other miRNAs w/seed CGAGGAG); mir-17; mir-187; miR-187-3p (miRNAs w/seed CGUGUCU); miR-197-3p (and other miRNAs w/seed UCACCAC); mir-221; miR-221-3p (and other miRNAs w/seed GCUACAU); mir-26; mir-28; mir-339; miR-339-3p (miRNAs w/seed GAGCGCC); miR-339-5p (and other miRNAs w/seed CCCUGUC); mir-361; miR-361-5p (miRNAs w/seed UAUCAGA); miR-409-3p (miRNAs w/seed AAUGUUG); miR-487b-3p (miRNAs w/seed AUCGUAC); miR-494-3p (miRNAs w/seed GAAACAU); miR-93-3p (miRNAs w/seed CUGCUGA); NR0B2 (nuclear receptor subfamily 0 group B member 2); RPS15 (ribosomal protein S15); TRIM71 (tripartite motif containing 71); XBP1 (X-box binding protein 1). B: MicroRNAs and gene network targeting VEGF: ADGRG1 (adhesion G protein-coupled receptor G1); calcifediol; FADS2 (fatty acid desaturase 2); FNDC3A (fibronectin type III domain containing 3A); FSH (follicle-stimulating hormone); Insulin; let-7a-5p (and other miRNAs w/seed GAGGUAG); MAP2K1/2; MEK1/2; MKK1/2; miR-125b-5p (and other miRNAs w/seed CCCUGAG); miR-126a-3p (and other miRNAs w/seed CGUACCG); mir-130; miR-155-5p (miRNAs w/seed UAAUGCU); miR-17-5p (and other miRNAs w/seed AAAGUGC); miR-185-5p (and other miRNAs w/seed GGAGAGA); miR-191-5p (and other miRNAs w/seed AACGGAA); miR-210-3p (miRNAs w/seed UGUGCGU); miR-23a-3p (and other miRNAs w/seed UCACAUU), miR-130a*; miR-26a-5p (and other miRNAs w/seed UCAAGUA); miR-1297; miR-30c-5p (and other miRNAs w/seed GUAAACA); mir-363; mir-423; miR-423-3p (miRNAs w/seed GCUCGGU); miR-432 (and other miRNAs w/seed CUUGGAG); miR-532-5p (and other miRNAs w/seed AUGCCUU), miR-6339; miR-92a-3p (and other miRNAs w/seed AUUGCAC), miR-25, miR-32, miR-363, miR-367; SLC38A1 (solute carrier family 38 member 1); Smad2/3 (TGF beta signaling proteins); SMAD6/7 (TGF beta signaling proteins); SYPL1 (synaptophysin like 1); TP53I11 (tumor protein p53 inducible protein 11); TUSC2 (tumor suppressor candidate 2); Vegf (VEGF mRNA). C: Inflammatory pathway - Recruitment and activation of eosinophils, Th2 lymphocytes, and macrophages: Histamine; IL-13 (interleukin-13); IL-4 (interleukin-4); IL-5 (interleukin-5); IL17A (interleukin-17A, CTLA-8); IL17B (interleukin-17B); Leukotrienes; TNFα (tumor necrosis factor α); VEGFA (vascular endothelial growth factor A).