Table 4 of Davoudi, Mol Vis 2018; 24:59-74.
Gene | Chr | SNP | Ref/ Alternate Allele | Anterior Uveitis versus Controls | Anterior Uveitis versus Other (Intermediate, Posterior and Pan) Uveitis | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ref Allele Freq, Cases (n=24) | Ref Allele Freq, Controls (n=32) | OR | 95% CI | Pcorr | Ref Allele Freq, Ant Uveitis Cases (n=24) | Ref Allele Freq, Other Uveitis (n=21) | OR | 95% (CI) | Pcorr | ||||
CFH Y402H | 1 | rs1061170 | C/T | 0.33 | 0.38 | 0.83 | 0.38–1.83 | 1.00 | 0.33 | 0.36 | 0.90 | 0.38–2.15 | 0.86 |
IL23R | 1 | rs11209026 | A/G | 0.09 | 0.05 | 2.03 | 0.43–9.57 | 0.29 | 0.09 | 0.05 | 2.00 | 0.35–11.54 | 0.36 |
IL23R | 1 | rs11465804 | G/T | 0.08 | 0.06 | 1.36 | 0.32–5.75 | 0.73 | 0.08 | 0.05 | 1.82 | 0.32–10.47 | 0.43 |
IL23R | 1 | rs7517847 | G/T | 0.39 | 0.30 | 1.52 | 0.48–4.78 | 0.50 | 0.39 | N/A | N/A | N/A | 1.00 |
TGF-β2 | 1 | rs1891467 | G/A | 0.39 | 0.23 | 2.06 | 0.89–4.76 | 0.09 | 0.39 | 0.24 | 2.02 | 0.79–5.13 | 0.16 |
CCR 5 | 3 | rs1799987 | A/G* | 0.52 | 0.45 | 1.31 | 0.62–2.78 | 0.50 | 0.48 | 0.50 | 0.92 | 0.40–2.11 | 1.00 |
BTNL2 | 6 | rs9268480 | T/C | 0.34 | 0.22 | 1.85 | 0.78–4.37 | 0.14 | 0.34 | 0.29 | 1.29 | 0.52–3.23 | 0.63 |
BTNL2 | 6 | rs9268482 | T/A | 0.34 | 0.22 | 1.85 | 0.78–4.37 | 0.14 | 0.34 | 0.29 | 1.29 | 0.52–3.23 | 0.86 |
HLA- DQA1 | 6 | rs17843604 | C/T* | 0.46 | 0.52 | 0.79 | 0.38–1.68 | 0.45 | 0.54 | 0.43 | 1.58 | 0.68–3.63 | 0.20 |
HLA- DRA | 6 | rs7192 | T/G | 0.23 | 0.47 | 0.33 | 0.14–0.79 | 0.007 | 0.23 | 0.48 | 0.32 | 0.13–0.82 | 0.02 |
HLA- DRA | 6 | rs7194 | G/A | 0.23 | 0.47 | 0.33 | 0.14–0.79 | 0.006 | 0.23 | 0.48 | 0.32 | 0.13–0.82 | 0.02 |
HLA- DRB1 | 6 | rs615672 | C/G | 0.35 | 0.48 | 0.58 | 0.27–1.26 | 0.34 | 0.35 | 0.45 | 0.66 | 0.28–1.55 | 0.48 |
HLA- DRB5 | 6 | rs17203612 | T/A | 0.50 | 0.25 | 3.00 | 1.32–6.80 | 0.014 | 0.50 | 0.31 | 2.23 | 0.92–5.39 | 0.10 |
HSP-70/Hom | 6 | rs2075800 | T/C | 0.35 | 0.36 | 0.98 | 0.45–2.14 | 1.00 | 0.35 | 0.24 | 1.76 | 0.70–4.42 | 0.15 |
HSP-70/Hom | 6 | rs1043620 | T/C | 0.02 | 0.08 | 0.27 | 0.03–2.35 | 0.26 | 0.02 | 0.03 | 0.72 | 0.04–11.97 | 0.55 |
LTA | 6 | rs909253 | G/A | 0.42 | 0.36 | 1.27 | 0.59–2.75 | 0.64 | 0.42 | 0.60 | 0.49 | 0.21–1.13 | 0.12 |
NOTCH4 | 6 | rs715299 | G/T | 0.45 | 0.31 | 1.83 | 0.83–4.06 | 0.20 | 0.45 | 0.31 | 1.86 | 0.77–4.50 | 0.26 |
RAB23 | 6 | rs1040461 | T/C | 0.11 | 0.00 | N/A | N/A | 0.001 | 0.11 | 0.02 | 5.26 | 0.59–47.03 | 0.10 |
TNF-α | 6 | rs1800629 | A/G | 0.05 | 0.17 | 0.23 | 0.05–1.09 | 0.03 | 0.05 | 0.29 | 0.12 | 0.02–0.57 | 0.001 |
TLR4 | 9 | rs4986790 | G/A | 0.02 | 0.08 | 0.25 | 0.03–2.22 | 0.20 | 0.02 | 0.02 | 0.87 | 0.05–14.39 | 1.00 |
ANXA11 | 10 | rs2789679 | T/A | 0.33 | 0.41 | 0.73 | 0.33–1.60 | 0.34 | 0.33 | 0.29 | 1.25 | 0.51–3.07 | 0.86 |
ANXA11 | 10 | rs2573346 | A/G | 0.36 | 0.41 | 0.84 | 0.38–1.84 | 0.55 | 0.36 | 0.29 | 1.43 | 0.58–3.54 | 0.86 |
ANXA11 | 10 | rs1049550 | A/G | 0.39 | 0.41 | 0.92 | 0.42–2.02 | 0.64 | 0.39 | 0.29 | 1.57 | 0.64–3.89 | 0.73 |
ANXA11 | 10 | rs61860052 | A/C | 0.19 | 0.03 | 7.15 | 1.47–34.86 | 0.004 | 0.19 | 0.07 | 3.00 | 0.75–11.92 | 0.09 |
ANXA11 and PLAC9 | 10 | rs1953600 | T/C | 0.36 | 0.41 | 0.84 | 0.38–1.84 | 0.55 | 0.36 | 0.29 | 1.43 | 0.58–3.54 | 0.86 |
C10ORF67/10p12.2 | 10 | rs1398024 | T/G | 0.23 | 0.20 | 1.17 | 0.47–2.89 | 0.86 | 0.23 | 0.19 | 1.26 | 0.45–3.51 | 1.00 |
IL2RA | 10 | rs12722489 | T/C | 0.16 | 0.08 | 2.23 | 0.66–7.55 | 0.18 | 0.16 | 0.10 | 1.80 | 0.49–6.66 | 0.31 |
CDCC88B | 11 | rs671976 | A/G | 0.41 | 0.50 | 0.69 | 0.32–1.50 | 0.32 | 0.59 | 0.40 | 2.12 | 0.90–5.02 | 0.11 |
CDCC88B | 11 | rs479777 | C/T | 0.23 | 0.28 | 0.75 | 0.31–1.83 | 0.63 | 0.23 | 0.29 | 0.74 | 0.28–1.94 | 0.69 |
OS9 | 12 | rs11172300 | T/C | 0.34 | 0.36 | 0.92 | 0.41–2.06 | 0.69 | 0.34 | 0.38 | 0.84 | 0.35–2.03 | 0.64 |
OS9 | 12 | rs701007 | A/C | 0.38 | 0.42 | 0.82 | 0.38–1.77 | 0.44 | 0.38 | 0.43 | 0.80 | 0.34–1.86 | 0.48 |
OS9 | 12 | rs799265 | G/A | 0.40 | 0.42 | 0.90 | 0.42–1.92 | 0.78 | 0.40 | 0.48 | 0.72 | 0.31–1.67 | 0.38 |
TGF-β3 | 14 | rs3917200 | G/A | 0.23 | 0.09 | 2.84 | 0.95–8.52 | 0.07 | 0.23 | 0.12 | 2.18 | 0.68–7.01 | 0.20 |
TGF-β3 | 14 | rs3917165 | T/C | 0.18 | 0.08 | 2.62 | 0.80–8.64 | 0.07 | 0.18 | 0.05 | 4.44 | 0.89–22.31 | 0.03 |
HERC2 | 15 | rs916977 | T/C | 0.32 | 0.30 | 1.11 | 0.48–2.54 | 1.00 | 0.32 | 0.33 | 0.93 | 0.38–2.30 | 0.86 |