Figure 5 of Gong, Mol Vis 2018; 24:574-586.


Figure 5. Effect of GABA receptor antagonists on the IOP and retinal ganglion cells of the ipsilateral eye in the chronic high IOP rat model. A: Intraocular pressure (IOP) was measured once a week after surgery (4 weeks + dimethyl sulfoxide (DMSO) versus 4 weeks + gabazine, *p<0.01; 4 weeks + DMSO versus 4 weeks + CGP55845, *p<0.01). B and C: The retinal cross sections were stained with BRN3A or terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL). D and E: The number of BRN3A- and TUNEL-positive cells (4 weeks + DMSO versus 4 weeks + gabazine, *p<0.01; 4 weeks versus 4 weeks + CGP55845, *p<0.01). The data are expressed as mean ± standard error of the mean (SEM), n=6 per group. 4w + gabazine group: with gabazine injection into the ARC, 4w + CGP55845 group: chronic high IOP rats with gabazine injection, 4w + DMSO: chronic high IOP rats with DMSO injection, 4w group: chronic high IOP rats without injection.