Table 3 of Daull, Mol Vis 2018; 24:459-470.

Table 3. Effects of CE-CKC emulsions on marker secretion by inflammatory or corneal epithelial cells upon stimulation.

Cell type
(Stimulation) Marker % Of marker secretion inhibition
CE-CKC
0.002% CE-CKC
0.005% Reference compound
PBMCs
(anti-CD3/28)   CsA
IL2 22±2 37±5* 79±14**
IL10 8±7 44±13 >100***
IFNγ 42±1* 55±6** 99***
TNFα 49±6*** 62±7*** 90±1***
PBMCs
(LPS)   DXM
IL6 8±2 63±7** 72±1*
IL8 11±6 64±10** 68±2***
IL12 5±5 61±8** 97±1***
TNFα 8±11 59±5* 85±1**
T cells CD4+
(anti-CD3/28)   CsA
IFNγ 12±2 15±5 >96***
TNFα 0±7 2±2 >88***
IL17 65±3** 98±1** 100***
HCE-2
(LPS)   IKK inhX
IL6 59±1** 53±2*** 105±0***
IL8 74±1*** 71±1*** 104±1***

Results are expressed as mean ± SEM of % of inhibition versus stimulated cells. *, p<0.05; **, p<0.01; ***, p<0.001. Abbreviations: CsA, cyclosporine A; DXM, dexamethasone; IKK inhX, IKK inhibitor X.

Daull, Mol Vis 2018; 24:459-470. http://www.molvis.org/molvis/v24/459

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