Figure 10 of Galicia, Mol Vis 2018; 24:443-458.


Figure 10. Diagrams of dscam and sdk expression patterns at 96 hpf. A,B: The dscam genes are all expressed in the GCL and inner INL, with occasional co-expression. A) shows the expression of dscamb and dscama where dscamb is also strongly expressed in the ONL. B) shows the expression of dscaml1 and dscama, which are co-expressed in a subset of cells in the basal INL. Dcamb is also expressed in the ONL, and dscaml1 is also found in the outer INL. C-F) The sdk genes were all expressed in the GCL, basal INL, and CMZ. C)Sdk1a and sdk1b show very similar expression domains in the INL, GCL, and CMZ. D)Sdk1a and sdk2b expression patterns were inferred from the almost complete co-expression of Sdk1a with Sdk1b, and the occasional co-expression of sdk1b and sdk2b, which indicates occasional co-expression in some cells in the GCL, INL, and CMZ of sdk1a and sdk2b. However, only sdk2b is present in the ONL. E)Sdk2a and sdk1b expression patterns were inferred from the almost complete co-expression of sdk2a with sdk2b and the occasional co-expression of sdk2b and sdk1b, which indicates occasional co-expression in some cells in the GCL, INL, and CMZ of sdk2a and sdk1b. However, only sdk2a is present in the ONL. F)Sdk2a and sdk2b also show similar expression domains in the INL, GCL, ONL, and CMZ of all developmental stages examined, along with expression in the ONL of 96 hpf larvae. G,H) The expression patterns of dscam and sdk genes are not mutually exclusive. G)Dscamb and sdk1b are sporadically co-expressed in some cells in the GCL and basal INL, while only dscamb is expressed in the ONL and only sdk1b is expressed in the CMZ. H)Dscamb and sdk2b are occasionally co-expressed in some cells in the GCL, basal INL, and ONL; however, only sdk2b is found in the CMZ. Abbreviations: hpf=hours post fertilization; Dscam=Down syndrome cell adhesion molecule; Sdk=sidekick; INL=inner nuclear layer; GCL=ganglion cell layer; ONL=outer nuclear layer, CMZ=ciliary marginal zone.