Figure 5. Structural and dynamic effects of methylation on the RHO promoter. A: Density plots for the major groove. B: The methylated major groove. C: The minor groove. D: Methylated minor groove widths for the methylated. The nucleotides within the CRX binding region are shown in green, and the methylation site is indicated in magenta. The mean groove width for each groove during the simulation is indicated as a dashed vertical line.