Figure 1. UCSC Genome Browser views of the
RHO (
A) and the 5′ region of
PDE6B (
B) photoreceptor-specific genes in the human hg19 genome assembly. Genes are oriented with the transcriptional start site on
the left. From top to bottom, data tracks display 1) human hg19 genome coordinates, 2) human adult retina RNA sequencing data
displayed as determined by Farkas et al. [
23], 3) predicted CRX binding regions (CBRs), 4) previously validated CRX binding motifs in the
RHO locus (black) or predicted CRX binding motifs in the
PDE6B locus, 5) annotated genes and isoforms, and 6) evolutionarily conserved sequences averaged between 100 vertebrate species.
Regions analyzed using bisulfite (BS) pyrosequencing are indicated with light blue highlighting.