Figure 5. The expression levels of type I and II IFNs in the control, voriconazole, and voriconazole plus FK506 groups in fungal keratitis. The mRNA levels of type I interferons (IFNs), including IFN-α (A) and IFN-β (B), and the type II IFN IFN-γ (C; normalized to β-actin), as well as the protein levels and band intensity of IFN-β (D), were reduced by voriconazole and FK506 in the murine fungal keratitis model at day 1, day 3, day 5, and day 7 post-infection. The data are the mean ± standard error of the mean (SEM) and represent three individual experiments with six animals/group/time. *, p<0.05; **, p<0.01; ***, p<0.001. IDV, integrated density value.