Figure 4. Clinical progression of and pathological changes in C57BL/6 mice after Aspergillus fumigatus infection in the control, voriconazole, and voriconazole plus FK506 groups. Ocular inflammatory responses (A), clinical scores (B), and pathological changes (C) were alleviated in the voriconazole plus FK506 group, followed by the voriconazole group and the FK506 group, in the murine fungal keratitis model at day 1, day 3, day 5, and day 7 post-infection. The data are the mean ± standard error of the mean (SEM) and represent three individual experiments with six animals/group/time. *, p<0.05; **, p<0.01; ***, p<0.001.