Table 2 of
Donahue, Mol Vis 2017; 23:987-1005. Table 2 of
Donahue, Mol Vis 2017; 23:987-1005.
Table 2. Highly represented genes between optic nerve injury (ONI) and CNS neurodegenerative disease (ND) data sets are listed.
| Gene | Average FC (Min - Max) | Associated GO Terms |
|---|---|---|
| C1QB | 3.68 (1.99–12.58) | Complement Activation, Innate Immune Response |
| CD68 | 3.55 (1.80–13.15) | Cellular Response to Organic Substance |
| CP | 3.13 (1.36–12.73) | Ferroxidase Activity, Cellular Iron Ion Homeostasis, Aging |
| CSF1R | 2.71 (1.52–10.91) | Inflammatory Response, Cellular Proliferation, Axon Guidance |
| CTSS | 3.85 (1.47–18.95) | Toll-Like Receptor Signaling Pathway, Antigen Processing and Presentation, Extracellular Matrix Dissassembly |
| DECR1 | 1.63 (1.18–2.55) | NADPH Binding, Protein Homotetramerization |
| DUSP15 | 1.63 (1.18–2.10) | Transforming Growth Factor Beta Receptor Signaling Pathway, Positive Regulation of JNK Cascade |
| HLA-A | 2.85 (1.47–7.67) | Immune Response, Antigen Processing and Presentation of Peptide Antigen via MHC class I |
| LAPTM5 | 2.52 (1.54–5.63) | Protein Binding, Transport |
| LY86 | 2.78 (1.44–11.51) | Apoptotic Process, Innate Immune Response |
| MPEG1 | 3.24 (1.49–15.53) | Integral Component of Membrane |
| MSN | 1.91 (1.21–3.73) | Leukocyte Cell-Cell Adhesion, Leukocyte Migration |
| SERPINA3 | 6.19 (1.48–12.92) | Inflammatory Response, Acute Phase Response, Platelet Degranulation |
| SESN3 | 1.55 (1.14–2.55) | Cellular Response to Amino Acid Stimulus, Negative Regulation of TORC1 signaling, Regulation of Response to Reactive Oxygen Species |
| TYROBP | 3.00 (1.79–12.05) | Cellular Defense Response, Intracellular Signal Transduction, Innate Immune Response |