Figure 5. Leading-edge subset proteins from the Human Phenotype Ontology gene sets implicated at 6 h. The heat map shows the leading-edge proteins from the four gene sets that were significantly enriched at the top or bottom of the protein list ranked by correlation with refraction at 6 h (abnormal electroretinogram, nyctalopia, photophobia, and arrhythmia). Heat map intensity values are plotted below the corresponding refraction measure for each sample. The panels to the right show the correlation of individual proteins with refraction, and provide further information on phenotype and disease associations (as listed in the Human Phenotype Ontology database; human-phenotype-ontology.github.io/). CCM = congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome, MELAS = mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, FARPA = fundus albipunctatus retinitis punctata albescens.