Figure 7. Western blot analysis of rat retinas. Diabetes caused a significant increase in the expression of ICAM-1 in the diabetic rats (D) compared to the non-diabetic controls (C; *p<0.05; Mann–Whitney U test). The diabetes-induced upregulation of ICAM-1 is attenuated in glycyrrhizic acid (GA)-fed diabetic rats (p<0.05; Mann–Whitney U test). The intravitreal administration of HMGB1 induced an upregulation of the expression of ICAM-1 compared to the intravitreal administration of PBS (*p<0.05; Mann–Whitney U test). A representative set of samples is shown. Results are expressed as the mean ± SD of 7–8 rats in each group.