Figure 2. H₂O₂-induced cell death is partially rescued by MEL and IIK7. A: Cell viability after 2 h of treatment with H₂O₂. Asterisks indicate a significant effect H₂O₂-inducing cell death (one-way ANOVA and the Student–Newman–Keuls (SNK) test; p<0.05). B: Cell viability after 2 h of treatment with melatonin (MEL) and/or H₂O₂. Asterisks indicate a significant effect of MEL preventing H₂O₂-induced death (one-way ANOVA and the Student–Newman–Keuls (SNK) test; p<0.05). C: Cell viability after pretreatment with luzindole (LUZ), a melatonin antagonist, after 2 h of treatment with MEL and/or H₂O₂. Asterisks indicate significant differences compared to the control group (treated only with vehicle; one-way ANOVA and the SNK test; p<0.05). D: Cell viability after 2 h of treatment with IIK7 and/or H₂O₂. Asterisk indicates a significant effect of IIK7, which protects the cells from death (one-way ANOVA and the SNK test; p<0.05). In all the cases, results are shown as mean ± standard error of the mean (SEM; n=6).