Molecular Vision: Shpak, Mol Vis 2017; 23:799-809. Table 4

Table 4. CNTF concentrations in the biologic fluids (pg/ml) and the aqueous humor to lacrimal fluid ratio in the main group depending on the POAG stage.

Biologic fluid	POAG stage			P / P_adj
Biologic fluid	1/2. Early to moderate (n=21)	3. Advanced (n=18)	4. Severe (n=16)	P / P_adj
Aqueous humor
mean±SD	44.6±25.9	45.2±31.6	27.7±14.6	NS /
mean (adjusted)	45.3	42.7	28.2	0.028 ^b
range	4.6–130	10.8–135.2	3.4–48.8
median (IQR)	41.4 (30.6–54.7)	38.8 (26.6–46.4)	25.4 (16–38.1)
Lacrimal fluid
mean±SD	28.5±14.6 ^a	27.5±16.8	19.9±11.8 ^a	0.041 ^c /
mean (adjusted)	28.3	26.6	22.7	NS
range	3.2–67.6	7.6–84.4	4.4–52.8
median (IQR)	28.5 (23.1–35.9)	23.7 (20–26.3)	20.0 (13.2–23.8)
Aqueous humor / lacrimal fluid ratio
mean±SD	1.89±1.47 ^a	1.68±0.75	1.44±0.62 ^a	NS /
mean (adjusted)	1.91 ^d	1.58	1.49	NS
range	0.56–6.88	0.45–3.48	0.66–2.77
median (IQR)	1.50 (1.28–1.78)	1.58 (1.28–1.93)	1.26 (1.07–1.75)
Blood serum
mean±SD	4.60±2.24	6.32±4.01	5.78±2.76	NS /
mean (adjusted)	3.21	5.19	4.21	NS
Maximum	11.6	20.3	10.6
median (IQR)	3.90 (2.70–5.60)	4.80 (3.80–6.60)	4.50 (3.20–8.00)
n censored	5	2	3

Statistical analysis was performed by Kruskal–Wallis test with post hoc pairwise comparisons by Holm method; CNTF in blood serum was compared by the generalized Wilcoxon test SD – standard deviation; IQR – interquartile range; n censored - number of observations below the minimum quantifiable value 2.5 pg/ml; NS – non-significant; means are adjusted by age, sex, IOP, medical, laser, and surgical treatment; P_adj – P for adjusted values ^a One case excluded with CNTF in lacrimal fluid not examined ^b P_{adj 1/2–4}=0.010 ^c P_1/2–4=0.017 ^d Without two extreme outliers, mean±SD=1.43±0.35, mean (adjusted)=1.45.