Molecular Vision: Wong, Mol Vis 2017; 23:718-739. Table 1

Table 1. Antioxidant supplement compositions*

Antioxidant Supplement: 6 weeks mg/kg body weight
Group 1	Βeta-carotene	Vitamin C	Vitamin E	Zn⁺⁺	Cu⁺⁺	Rosemary
AREDS (28)	0.29	7.53	6.67	1.44	0.03	-
AREDS Antiox. (28)	0.29	7.53	6.67	-	-	-
Zinc Oxide (28)	-	-	-	1.44	-	-
Group 2
Rosemary (18)	-	-	-	-	-	17
AREDS + Rosemary (20)	0.29	7.53	6.67	1.44	0.03	17
Zinc + Rosemary (20)	-	-	-	1.44	-	17
Antioxidant Supplement: 1 week mg/kg body weight
Group 3
AREDS (12)	0.29	7.53	6.67	1.44	0.03	-
Rosemary (6)	-	-	-	-	-	34
AREDS + Rosemary (10)	0.29	7.53	6.67	1.44	0.03	34
AREDS + Ursolic (6)	0.29	7.53	6.67	1.44	0.03	5.3 (ursolic)
AREDS + Carnosic (12)	0.29	7.53	6.67	1.44	0.03	7.9 / 15.8 (carnosic)

*AREDS, AREDS antioxidants (Antiox.) and rosemary were solubilized with vehicle (1% Tween 80/16% ethanol/ 25% ROPUFA). Zinc oxide and copper oxide levels per AREDS1 formula [6]. Zinc oxide was dissolved in distilled water [25]. Carnosic acid and ursolic acid were solubilized with 50% pure ethanol/ 50% ROPUFA. Weanling male Sprague-Dawley rats were supplemented for 6 weeks before intense light exposure or sacrifice for gene array analysis. Short-term supplementation was for 1 week prior to intense light treatment and subsequent analysis. The numbers in parenthesis indicate the n for each sub-group of dietary treatment. Comparable numbers of vehicle and AREDS fed rats were used for these experiments.