To access the data, click or select the words “Appendix 4.” Heme-oxygenase (HO-1) immunoreactivity determined 2 days and 2 weeks after intense light exposure of rats treated with vehicle (V), AREDS (A), or AREDS + carnosic acid (A+C). Two days after light exposure HO-1 staining was greater in V and AREDS treated rat retinas than in those treated with A+C. HO-1 activity was not present in any samples 2 weeks after photo-oxidative challenge.