Figure 3. Molecular and cellular functions being upregulated in tumor biopsies versus multicellular tumor spheroids (upper left panel), multicellular tumor spheroids versus tumor biopsies (upper right panel), multicellular tumor spheroids versus adherent cultures (lower left panel), and adherent cultures versus multicellular tumor spheroids (lower right panel). The number of molecules upregulated is shown in brackets. MCTS = tumors cultivated as multicellular tumor spheroids; adherent cultures = adherent cultivated tumors; tumor biopsies = uncultured primary tumor tissue.