Figure 2. Clinical examinations of patients with severe FEVR. A: B-scan ultrasonographic of the proband in family A reveals an irregular peripheral wall of the eyeball and persistent fetal vasculature with the hyaloid artery. B: Fundus image of the proband in family A. C: The same for family B. D: Spectral domain optical coherence tomography (SD-OCT) detected retinal detachment and hyperreflective epiretinal membrane-like appearance in the inner surface of the retina. E: Fundus fluorescein angiography (FFA) shows the various vascular branches of the posterior pole retina. The temporal peripheral retinal shows nonperfusion zones along with abnormal new blood vessels and fluorescence leakage.