Table 3 of
Samuel, Mol Vis 2017; 23:60-89. Table 3 of
Samuel, Mol Vis 2017; 23:60-89.
Table 3. Selected downregulated genes in the differentiated RPE cells.
| Gene | Gene Name | Biological Function | p-value | 4 Days | 4 Months | FC 4M/4D |
|---|---|---|---|---|---|---|
| Cell Cycle | ||||||
| TGFBI | Transforming Growth Factor | Cell cycle | 2.01E-06 | 417.62 | 19.64 | 0.047 |
| SERPINE1 | Serpin Peptidase | Inhibitor of fibrinolysis | 1.48E-05 | 255.38 | 13.21 | 0.052 |
| TAGLN | Transgelin | Cell cycle | 3.11E-06 | 181.82 | 8.52 | 0.047 |
| NPPB | Natriuretic Peptide B | Cell proliferation | 2.07E-06 | 162.61 | 0.24 | 0.001 |
| CDK1 | Cyclin-Dependent Kinase 1 | Cell cycle | 6.96E-05 | 37.73 | 1.22 | 0.033 |
| CPA4 | Carboxypeptidase A4 | Proliferation | 6.31E-07 | 37.03 | 1.39 | 0.038 |
| UBE2C | Ubiquitin-Conjugating Enzyme | Cell cycle | 1.03E-06 | 20.57 | 0.17 | 0.008 |
| CENPF | Centromere Protein F | Cell cycle | 4.56E-04 | 20.27 | 1.98 | 0.098 |
| CEP55 | Centrosomal Protein 55 kDa | Cell cycle | 1.21E-05 | 18.57 | 0.31 | 0.017 |
| CDC6 | Cell Division Cycle 6 | Cell cycle | 2.06E-05 | 15.16 | 0.72 | 0.047 |
| CCNB2 | Cyclin B2 | Cell cycle | 1.41E-05 | 12.76 | 0.45 | 0.036 |
| BUB1 | BUB1 Serine/Threonine Kinase | Cell cycle | 4.44E-06 | 10.99 | 0.58 | 0.053 |
| BIRC5 | Baculoviral IAP Repeat | Cell cycle | 2.84E-05 | 10.17 | 0.13 | 0.013 |
| CCNE2 | Cyclin E2 | Cell cycle | 3.27E-05 | 9.71 | 0.46 | 0.047 |
| CDC20 | Cell Division Cycle 20 | Cell cycle | 9.49E-06 | 8.60 | 0.24 | 0.028 |
| MKI67 | Marker of Proliferation K-67 | Cell proliferation | 2.19E-04 | 5.45 | 0.16 | 0.029 |
| AURKB | Aurora Kinase B | Cell Cycle | 5.15E-08 | 5.12 | 0.13 | 0.025 |
| E2F1 | E2F Transcription Factor 1 | Cell cycle | 1.29E-07 | 4.38 | 0.28 | 0.064 |
| PLK1 | Polo-Like Kinase 1 | Cell cycle | 5.67E-05 | 2.91 | 0.12 | 0.041 |
| CDC25C | Cell Division Cycle 25C | Cell cycle | 1.71E-04 | 2.31 | 0.08 | 0.033 |
| Transcription Factors | ||||||
| ANKRD1 | Ankyrin Repeat Domain 1 | Transcription | 1.49E-07 | 326.21 | 7.39 | 0.023 |
| HIST2H3C | Histone Cluster 2 H3c | Transcription | 6.75E-07 | 66.71 | 1.12 | 0.017 |
| TOP2A | Topoisomerase (DNA) II Alpha | Transcription | 6.18E-05 | 37.41 | 0.74 | 0.020 |
| PTTG1 | Pituitary Tumor-Transforming 1 | Transcription | 1.99E-05 | 31.15 | 1.78 | 0.057 |
| JUN | Jun Proto-Oncogene | Transcription | 4.00E-05 | 29.84 | 2.79 | 0.093 |
| RRM2 | Ribonucleotide Reductase M2 | Transcription | 1.06E-05 | 14.39 | 0.71 | 0.049 |