Table 2 of Samuel, Mol Vis 2017; 23:60-89.


Table 2. Selected upregulated genes in the differentiated RPE cells.

Gene Gene Name Biological Function p-value 4 Days 4 Months FC 4M/4D
Vitamin A Metabolism
RPE65 Retinal Pigment Epithelium-Specific Protein 65kDa Visual pigment regeneration 1.32E-05 0.01 9.75 1462.50
TTR Transthyretin Retinol transport 1.04E-05 0.00 3.98 1326.67
RGR Retinal G Protein Coupled Receptor Receptor for retinal 5.43E-04 0.02 15.98 959.00
RLBP1 Retinaldehyde Binding Protein 1 Retinol regeneration 2.50E-04 0.39 198.37 504.32
BCMO1 Beta-Carotene 15,15-Monooxygenase 1 Beta-carotene metabolism 8.39E-06 0.13 35.68 281.66
RDH5 Retinol Dehydrogenase 5 Retinal biosynthesis 2.76E-04 4.02 100.39 24.95
LRAT Lecithin Retinol Acyltransferase Esterification of all-trans-retinol 6.55E-04 0.41 9.13 22.44
RBP1 Retinol Binding Protein 1, Cellular Retinol transport 1.37E-04 12.32 37.44 3.04
STRA6 Stimulated by Retinoic Acid 6 Retinol transport 1.38E-02 0.12 0.25 2.14
RDH10 Retinol Dehydrogenase 10 Retinal biosynthesis 1.65E-05 90.34 181.83 2.01
Phagocytosis
COLEC12 Collectin Sub-Family Member 12 Phagocytosis 2.32E-05 0.64 94.98 148.40
PLA2G5 Phospholipase A2, Group V Phagocytosis 1.42E-07 0.12 10.88 93.29
TUB Tubby Bipartite Transcription Factor Phagocytosis 5.67E-06 0.01 0.45 67.00
MERTK MER Proto-Oncogene, Tyrosine Kinase Phagocytosis 1.73E-05 0.42 7.00 16.81
ITGAV Integrin, Alpha V Signal transduction 5.63E-04 3.08 35.91 11.65
Pigmentation
DCT Dopachrome Tautomerase Melanin synthesis 1.50E-04 0.02 47.34 2840.20
TRPM1 Transient Receptor Potential Cation Channel, M1 Melanin synthesis 4.01E-06 0.01 36.23 2717.26
OCA2 Melanocyte-Specific Transporter Protein Melanosome maturation 1.01E-03 0.00 4.06 1352.22
TYRP1 Tyrosinase-Related Protein 1 Melanin biosynthesis 1.28E-06 3.77 3749.82 995.53
TRPM3 Transient Receptor Potential Cation Channel, M3 Calcium signaling 6.89E-05 1.50 647.81 432.84
TYR Tyrosinase Melanin biosynthesis 6.43E-08 0.77 273.39 356.60
PMEL Premelanosome Protein Biogenesis of melanosomes 6.45E-05 1.27 136.65 107.60
SLC45A2 Solute Carrier Family 45, Member 2 Melanin biosynthesis 1.04E-04 1.42 69.92 49.12
Cell Differentiation
DAPL1 Death Associated Protein-Like 1 Epithelial cell differentiation 1.67E-05 0.34 663.95 1933.85
CP Ceruloplasmin (Ferroxidase) Iron metabolism 2.33E-04 0.51 136.22 265.36
DSC1 Desmocollin 1 Cell adhesion 4.30E-06 0.12 30.33 245.92
CLDN2 Claudin 2 Tight junction 2.06E-03 0.02 3.51 210.8
SERPINF1 PEDF Anti-angiogenesis 1.61E-05 7.76 1478.63 190.46
FGFR2 fibroblast growth factor R2 Cell cycle 2.28E-05 0.12 17.51 142.00
BEST1 Bestrophin 1 Electron transport 3.41E-04 0.30 13.06 44.01
CST3 Cystatin c Protease inhibitor 1.35E-04 66.06 2013.58 30.48
CDH3 Cadherin 3, P-Cadherin Cell adhesion 1.44E-03 0.02 0.50 24.83
CDH1 Cadherin E Cell adhesion 8.79E-05 0.04 0.57 13.23
RPE-related Transcription Factor
TFEC Transcription Factor Transcriptional regulation 1.91E-07 0.08 4.63 57.88
SOX9 SRY -Box 9 Transcriptional regulation 1.21E-03 4.90 21.77 4.44
OTX2 Orthodenticle Homeobox 2 Sensory organ development. 8.13E-07 38.35 150.33 3.92
MITF Microphthalmia-Associated Melanocyte development 1.21E-07 50.91 119.18 2.34
CRX Cone-Rod Homeobox Transcriptional regulation 8.82E-03 1.07 1.33 1.25
PAX6 Paired Box 6 Eye development 1.79E-02 28.42 33.87 1.19