Table 2 of Samuel, Mol Vis 2017; 23:60-89.
Gene | Gene Name | Biological Function | p-value | 4 Days | 4 Months | FC 4M/4D |
---|---|---|---|---|---|---|
Vitamin A Metabolism | ||||||
RPE65 | Retinal Pigment Epithelium-Specific Protein 65kDa | Visual pigment regeneration | 1.32E-05 | 0.01 | 9.75 | 1462.50 |
TTR | Transthyretin | Retinol transport | 1.04E-05 | 0.00 | 3.98 | 1326.67 |
RGR | Retinal G Protein Coupled Receptor | Receptor for retinal | 5.43E-04 | 0.02 | 15.98 | 959.00 |
RLBP1 | Retinaldehyde Binding Protein 1 | Retinol regeneration | 2.50E-04 | 0.39 | 198.37 | 504.32 |
BCMO1 | Beta-Carotene 15,15-Monooxygenase 1 | Beta-carotene metabolism | 8.39E-06 | 0.13 | 35.68 | 281.66 |
RDH5 | Retinol Dehydrogenase 5 | Retinal biosynthesis | 2.76E-04 | 4.02 | 100.39 | 24.95 |
LRAT | Lecithin Retinol Acyltransferase | Esterification of all-trans-retinol | 6.55E-04 | 0.41 | 9.13 | 22.44 |
RBP1 | Retinol Binding Protein 1, | Cellular Retinol transport | 1.37E-04 | 12.32 | 37.44 | 3.04 |
STRA6 | Stimulated by Retinoic Acid 6 | Retinol transport | 1.38E-02 | 0.12 | 0.25 | 2.14 |
RDH10 | Retinol Dehydrogenase 10 | Retinal biosynthesis | 1.65E-05 | 90.34 | 181.83 | 2.01 |
Phagocytosis | ||||||
COLEC12 | Collectin Sub-Family Member 12 | Phagocytosis | 2.32E-05 | 0.64 | 94.98 | 148.40 |
PLA2G5 | Phospholipase A2, Group V | Phagocytosis | 1.42E-07 | 0.12 | 10.88 | 93.29 |
TUB | Tubby Bipartite Transcription Factor | Phagocytosis | 5.67E-06 | 0.01 | 0.45 | 67.00 |
MERTK | MER Proto-Oncogene, Tyrosine Kinase | Phagocytosis | 1.73E-05 | 0.42 | 7.00 | 16.81 |
ITGAV | Integrin, Alpha V | Signal transduction | 5.63E-04 | 3.08 | 35.91 | 11.65 |
Pigmentation | ||||||
DCT | Dopachrome Tautomerase | Melanin synthesis | 1.50E-04 | 0.02 | 47.34 | 2840.20 |
TRPM1 | Transient Receptor Potential Cation Channel, M1 | Melanin synthesis | 4.01E-06 | 0.01 | 36.23 | 2717.26 |
OCA2 | Melanocyte-Specific Transporter Protein | Melanosome maturation | 1.01E-03 | 0.00 | 4.06 | 1352.22 |
TYRP1 | Tyrosinase-Related Protein 1 | Melanin biosynthesis | 1.28E-06 | 3.77 | 3749.82 | 995.53 |
TRPM3 | Transient Receptor Potential Cation Channel, M3 | Calcium signaling | 6.89E-05 | 1.50 | 647.81 | 432.84 |
TYR | Tyrosinase | Melanin biosynthesis | 6.43E-08 | 0.77 | 273.39 | 356.60 |
PMEL | Premelanosome Protein | Biogenesis of melanosomes | 6.45E-05 | 1.27 | 136.65 | 107.60 |
SLC45A2 | Solute Carrier Family 45, Member 2 | Melanin biosynthesis | 1.04E-04 | 1.42 | 69.92 | 49.12 |
Cell Differentiation | ||||||
DAPL1 | Death Associated Protein-Like 1 | Epithelial cell differentiation | 1.67E-05 | 0.34 | 663.95 | 1933.85 |
CP | Ceruloplasmin (Ferroxidase) | Iron metabolism | 2.33E-04 | 0.51 | 136.22 | 265.36 |
DSC1 | Desmocollin 1 | Cell adhesion | 4.30E-06 | 0.12 | 30.33 | 245.92 |
CLDN2 | Claudin 2 | Tight junction | 2.06E-03 | 0.02 | 3.51 | 210.8 |
SERPINF1 | PEDF | Anti-angiogenesis | 1.61E-05 | 7.76 | 1478.63 | 190.46 |
FGFR2 | fibroblast growth factor R2 | Cell cycle | 2.28E-05 | 0.12 | 17.51 | 142.00 |
BEST1 | Bestrophin 1 | Electron transport | 3.41E-04 | 0.30 | 13.06 | 44.01 |
CST3 | Cystatin c | Protease inhibitor | 1.35E-04 | 66.06 | 2013.58 | 30.48 |
CDH3 | Cadherin 3, P-Cadherin | Cell adhesion | 1.44E-03 | 0.02 | 0.50 | 24.83 |
CDH1 | Cadherin E | Cell adhesion | 8.79E-05 | 0.04 | 0.57 | 13.23 |
RPE-related Transcription Factor | ||||||
TFEC | Transcription Factor | Transcriptional regulation | 1.91E-07 | 0.08 | 4.63 | 57.88 |
SOX9 | SRY -Box 9 | Transcriptional regulation | 1.21E-03 | 4.90 | 21.77 | 4.44 |
OTX2 | Orthodenticle Homeobox 2 | Sensory organ development. | 8.13E-07 | 38.35 | 150.33 | 3.92 |
MITF | Microphthalmia-Associated | Melanocyte development | 1.21E-07 | 50.91 | 119.18 | 2.34 |
CRX | Cone-Rod Homeobox | Transcriptional regulation | 8.82E-03 | 1.07 | 1.33 | 1.25 |
PAX6 | Paired Box 6 | Eye development | 1.79E-02 | 28.42 | 33.87 | 1.19 |