Figure 1. The developmental roles of embryonic eyelid closure. Failure of eyelid closure in embryogenesis causes truncated tarsal muscles, blunted LPS, and abnormal sclera insertion site of the IR muscles. The eye open-at-birth (EOB) mice also develop exposure-driven remodeling changes (bright blue) of the cornea, conjunctiva, and meibomian gland. Lel = lower eyelid, uel = upper eyelid, TM = tarsal muscle, LPS = levator palpebrae superioris, IO = inferior oblique, IR = inferior rectus, SR = superior rectus, SO = superior oblique, MG = meibomian gland, co = cornea, le = lens, re = retina.