Figure 5. Reduction in ocular factor B protein of monkeys treated with the factor B ASO for 13 weeks. Cynomolgus monkeys were dosed with saline (n = 4) or ION-588548 (n = 4) at 40 mg/kg/wk for 13 weeks. One whole eye from each monkey was used for total protein isolation. The factor B protein levels were measured with western blot.