Figure 4. Reduction in plasma factor B protein levels of cynomolgus monkeys treated with the factor B ASO for 13 weeks. Cynomolgus monkeys were dosed with saline (n = 6) or ION-588548 (n = 4) at 40 mg/kg/wk for 13 weeks. Plasma samples were obtained at days −6, 1, 30, 58, 72, and 86 of the study and analyzed for the level of factor B protein. Data presented as % of baseline (day −6) for the individual monkeys and mean ± standard error of the mean (SEM) for each time point.