Figure 4 of Santhanam, Mol Vis 2017; 23:39-51.


Figure 4. Analysis of EBM component mRNAs in the anterior stroma at 2 days after PRK with quantitative real-time PCR. Nidogen-1 (Nid-1) mRNA was not statistically significantly increased in the anterior stroma of −4.5D photorefractive keratectomy (PRK) or −9.0D PRK corneas compared with the unwounded control corneas at this early time point. The nidogen-2 (Nid-2), perlecan, and laminin α-3 (LAMA3) mRNAs were statistically significantly increased in the anterior stroma of the −4.5D PRK and −9.0D PRK corneas compared to the unwounded control corneas. The Nid-2 and LAMA3 mRNAs were statistically significantly increased in the anterior stroma at 2 days after surgery in the −9.0D PRK corneas compared with the −4.5D PRK corneas. (n = 4 for each group; ***, p<0.01; **`).